Effect of Solvent Composition on Solubility, Thermodynamics, Metastable Zone Width (MSZW) and Crystal Habit of L-Ascorbic Acid

This work investigates the effect of different solvent systems on solubility, thermodynamics, metastable zone width (MSZW), and crystal habit ascorbic acid, in order to help optimize its crystallization process. The solubility curves (MSZ) limits were determined experimentally using polythermal method pure solvents: water alcohols (methanol/ethanol/isopropanol), as well water-alcohol binary systems. decreases with increasing alcohol composition for all data correlated Jouyban–Acree model a function two variables: temperature composition. dissolution enthalpy (ΔHdiss), entropy (ΔSdiss), Gibbs free energy (ΔGdiss) Van’t Hoff models. thermodynamic properties increase lowest highest values obtained (20.52 kJ mol −1) isopropanol (35.33 mol−1), respectively. Pure solvents widen width, indicating high supersaturation required nucleation. Crystal images captured during cooling confirm cubic formation, whereas system promotes preferential growth along one crystallographic axis, leading elongated prism-shaped crystals methanol ethanol needle-shaped isopropanol.